Synoptic
Biosciences
Synoptic stands on a decade of peer-reviewed work that established protein-level measurement of biological aging, organ-specific health trajectories, and the molecular fingerprint of lifestyle and environment. Below: the foundational papers that anchor SYN-WAVE and our broader pipeline.
Our founding scientific bet is that the plasma proteome is the most actionable readout of human biology. These two papers — from our Founding CEO and our CTO — established the field's two core capabilities: population-scale proteomic genetics, and personal proteomic aging.
The paper identified 10,000+ protein-quantitative trait loci, mapped causal protein-disease relationships at unprecedented scale, and demonstrated that plasma proteins integrate genetic risk, environmental exposure, and emerging disease. It is the canonical reference for population-scale proteomic biomarker discovery.
Through dense longitudinal multi-omic profiling of healthy adults, the paper showed that biological aging is not a single number but a personal, system-specific trajectory — and that those trajectories can be detected, tracked, and (potentially) modified. This is the scientific backbone of Synoptic's longitudinal product thesis.
Organ-specific aging clocks. Proteomic disease prediction at population scale. Inflammation as a biological-age driver. The exposome as the dominant explainer of variance. These papers — from the Wyss-Coray, Snyder, Furman, and other labs that pioneered modern proteomic aging — anchor every measurement and signature in SYN-WAVE.